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| Author：臧晶晶 Release time：2020-06-01 Access times:299 |
| Name: | HUANG Chengdong Professor | Address: | Room 705, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, PR China | Tel: | 0551-63600743 | E-mail: | huangcd@ustc.tsg211.com | EDUCATION AND RESEARCH EXPERIENCE 1997-2001 | Dalian University of Technology
Bachelor，Industrial Catalysis | 2001-2004
2004-2010
2010-2012 | Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Master，Biochemical Engineering Auburn University Ph.D., Biochemistry Stony Brook University Department of Biochemistry and Cell Biology, Postdoctoral Fellow | 2012-2015
2015-2017
2017
| Rutgers University Department of Chemistry and Chemical Biology, Postdoctoral Fellow University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, Postdoctoral Fellow St. Jude Children’s Research Hospital, Department of Structural Biology, Associate Scientist
| 2017-present | University of Science and Technology of China School of Life Sciences, Professor |
RESEARCH INTERESTS Our current work primarily focuses on determination of the structural and dynamic basis for the function and assembly of large protein machineries. |
CURRENT RESEARCH PROJECTS 1. | Mechanistic studies of the interaction of the large dynamic molecular chaperone Hsp90 with its clients. General Program | 2. | Mechanistic study of clients transportation by the protein machine p97 using solution NMR. General Program |
REPRESENTATIVE PUBLICATIONS Huang, Chengdong; Kalodimos, Charalampos, G. Structures of Large Protein Complexes by NMR. Annu. Rev. Biophys. 46, 317-336(2017). Huang, Chengdong; Rossi, Paolo; Saio, Tomohide; Kalodimos, Charalampos, G. Structural basis for the antifolding activity of a molecular chaperone. Nature. 537, 202-206 (2016). Rath, Poonam; Huang, Chengdong; Wang, Tao; Wang, Tianzhi; Li, Huilin; Prados-Rosales, Rafael; Elemento, Olivier; Casadevall, Arturo; Nathan, Carl F. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci.USA. 110(49), E4790-4797 (2013). Huang, Chengdong*; Li, Guangtao*; Lennarz, William J. Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission. (*Equal contribution) Proc. Natl. Acad. Sci. USA. 109(25), 9792-9297 (2012). Li, Guangtao*; Huang, Chengdong*, Zhao, Gang; Lennarz, William J. Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97. (*Equal contribution) Proc. Natl. Acad. Sci. USA, 109(10), 3737-3741 (2012). Huang, Chengdong; Bhaskaran, Rajagopalan; Mohanty, Smita. Eukaryotic N-glycosylation Occurs Via membrane-anchored C-terminal domain of Stt3p subunit of oligosaccharyl transferase. J. Biol. Chem. 287(39), 32450-32458 (2012). Huang, Chengdong; Mohanty, Smita. Challenging the Limit: NMR Assignment of a 31 kDa Monomeric Helical Membrane Protein. J. Am. Chem. Soc. 132, 3662–3663 (2010).
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